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Answer: A controlled experiment is a scientific test conducted under controlled conditions, which means that only one (or few) fatigue is altered at a time, while all others are kept constant.
In some cases, it is not a good way to test a hypothesis using a controlled experiment (for practical or ethical reasons). In this case, a scientist can test the hypothesis by making predictions about patterns that can be observed in nature if the hypothesis is correct. Then, she or he can collect data to check if the pattern really exists.
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